Preparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules

The candesartan cilexetil belongs to class II of the biopharmaceutical classification system and bioavailability is 15% due to the poor aqueous solubility. The purpose of the study is to improve aqueous solubility by nano technology of solid lipid nanoparticle by solvent evaporation method. Here glyceryl monosterate (lipid), polaxemor 407, tweeen 80 (co-surfactant and surfactant respectively) and dichloro methane (organic solvent) are used for formulation. The nanoparticles of candesartan cilexetil are formulated to improve the oral bioavailability by preparing particles of nanosize range with good zeta potential. Phase contrast microscopy (PCM) analysis done to confirm the morphology of prepared solid lipid nanoparticles with free clusters. The lyophilizedcandesartan cilexetilsoilid lipid nonoparticles were filled into hard gelatin capsules and it test are complies with IP standards for capsules. In-vitro release studies of all the formulations are done to confirm its enhancement of in-vitro bioavailability, when compare to pure drug formulation 1.74 folds increase in bioavailability of prepared nanoparticles are noted.